Nd-Aldopentofuranosyl-N′-[p-(isoamyloxy) phenyl]-thiourea derivatives: potential anti-TB therapeutic agents

A Liav, SK Angala, PJ Brennan, M Jackson

文献索引：Liav, Avraham; Angala, Shiva K.; Brennan, Patrick J.; Jackson, Mary Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 8 p. 2649 - 2651

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被引用次数: 37

摘要

Thiocarlide (THC; N, N′-bis [p-(isoamyloxy) phenyl]-thiourea; also known as isoxyl) has been used in the past as anti-tuberculosis agent. In an effort to improve the therapeutic value of THC several N-pentofuranosyl-N′-[p-(isoamyloxy) phenyl]-thiourea derivatives were synthesized by coupling of an aniline derivative and pentofuranosyl isothiocyanates. The MIC values of the new products against M. tb indicate that this new approach to the ...