An enantioselective synthesis of the topically-active carbonic anhydrase inhibitor MK-0507: 5, 6-dihydro-(S)-4-(ethylamino)-(S)-6-methyl-4H-thieno [2, 3-b] thiopyran-2 …

TJ Blacklock, P Sohar, JW Butcher…

文献索引：Journal of Organic Chemistry, , vol. 58, # 7 p. 1672 - 1679

全文：HTML全文

被引用次数: 71

摘要

... An interesting and viable alternative for the installation of the ethylamino moiety on hydroxy sulfones 7a,b came via classic Ritter chemistry (Scheme 1). Initially, treatment of the 965 mixture of diastereomeric ... LO) Connon, NW Eastman Organic Chemical Bulletin 1972 ... 1676 J. Org ...