An enantioselective synthesis of the topically-active carbonic anhydrase inhibitor MK-0507: 5, 6-dihydro-(S)-4-(ethylamino)-(S)-6-methyl-4H-thieno [2, 3-b] thiopyran-2 …

TJ Blacklock, P Sohar, JW Butcher…

Index: Journal of Organic Chemistry, , vol. 58, # 7 p. 1672 - 1679

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Citation Number: 71

Abstract

... An interesting and viable alternative for the installation of the ethylamino moiety on hydroxy sulfones 7a,b came via classic Ritter chemistry (Scheme 1). Initially, treatment of the 965 mixture of diastereomeric ... LO) Connon, NW Eastman Organic Chemical Bulletin 1972 ... 1676 J. Org ...