Abstract A novel selective two-step synthesis of β-isothiocyanato ketones from α, β- unsaturated ketones has been developed. The synthesis includes preparation of β-azido ketones followed by reaction with triphenylphosphine and carbon disulfide. Treatment of the obtained β-isothiocyanato ketones with ammonia or methylamine gives corresponding hexahydro-4-hydroxypyrimidine-2-thiones. The latter are also prepared directly from β- ...
