Journal of inorganic biochemistry

Multiple spectroscopic and magnetic techniques show that chloroquine induces formation of the μ-oxo dimer of ferriprotoporphyrin IX

D Kuter, SJ Benjamin, TJ Egan

文献索引：Kuter, David; Benjamin, Stefan J.; Egan, Timothy J. Journal of Inorganic Biochemistry, 2014 , vol. 133, p. 40 - 49

全文：HTML全文

被引用次数: 6

摘要

Abstract Interaction of the antimalarial chloroquine (CQ) with ferriprotoporphyrin IX, Fe (III) PPIX, was investigated in aqueous solution (pH 7.4) and as a precipitate from aqueous medium at pH 5.0. In solution, spectrophotometric titrations indicated strong association (logK obs 13.3±0.2) and a Job plot gave a stoichiometry of 1: 2 CQ: Fe (III) PPIX. UV–visible absorbance and magnetic circular dichroism spectra of the complex were compared to ...