Catalysis with phosphine-containing amino acids in various “turn” motifs

…, SJ Greenfield, T Ohishi, SE Collibee…

文献索引：Agarkov, Anton; Greenfield, Scott J.; Ohishi, Takahiro; Collibee, Scott E.; Gilbertson, Scott R. Journal of Organic Chemistry, 2004 , vol. 69, # 23 p. 8077 - 8085

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被引用次数: 52

摘要

We have been actively involved in the development of parallel approaches for the discovery of phosphine ligands. Our approach has been based on the incorporation of phosphine- containing amino acids into peptide sequences that are designed to have stable secondary structures. We have examined helical and turn secondary structures and have reported that alkylation of cyclopentenyl acetate with dimethylmalonate can be catalyzed in high ...