A practical synthesis of the dual matrix metalloprotease/tumor necrosis factor inhibitor MMP090

JS Slade, JA Vivelo, DJ Parker, J Bajwa…

文献索引：Organic Process Research and Development, , vol. 9, # 5 p. 608 - 620

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被引用次数: 9

摘要

... Organic Process Research & Development. ... The original process was modified in that the sulfonyl chloride was added slowly to a hot (78 °C) solution of the substrate ... This addition-controlled procedure allowed for moderation of the gas evolution as well as the heat of the reaction ...