A practical synthesis of the dual matrix metalloprotease/tumor necrosis factor inhibitor MMP090

JS Slade, JA Vivelo, DJ Parker, J Bajwa…

Index: Organic Process Research and Development, , vol. 9, # 5 p. 608 - 620

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Citation Number: 9

Abstract

... Organic Process Research & Development. ... The original process was modified in that the sulfonyl chloride was added slowly to a hot (78 °C) solution of the substrate ... This addition-controlled procedure allowed for moderation of the gas evolution as well as the heat of the reaction ...

Discovery and development of a new class of potent, selectiv...

[Quattropani, Anna; Dorbais, Jerome; Covini, David; Pittet, Pierre-Andre; Colovray, Veronique; Thomas, Russell J.; Coxhead, Richard; Halazy, Serge; Scheer, Alexander; Missotten, Marc; Ayala, Guidon; Bradshaw, Charles; De Raemy-Schenk, Anne-Marie; Nichols, Anthony; Cirillo, Rocco; Tos, Enrico Gillio; Giachetti, Claudio; Golzio, Lucia; Marinelli, Paolo; Church, Dennis J.; Barberis, Claude; Chollet, Andre; Schwarz, Matthias K. Journal of Medicinal Chemistry, 2005 , vol. 48, # 24 p. 7882 - 7905]