Archiv der Pharmazie

Design of Benzothiazole??1, 3, 4??thiadiazole Conjugates: Synthesis and Anticonvulsant Evaluation

N Siddiqui, P Ahuja, S Malik, SK Arya

文献索引：Siddiqui, Nadeem; Ahuja, Priya; Malik, Sachin; Arya, Satish K. Archiv der Pharmazie, 2013 , vol. 346, # 11 p. 819 - 831

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被引用次数: 10

摘要

Abstract Various 2-[(6-substituted-1, 3-benzothiazol-2-yl) amino]-N-[5-substituted-phenyl-1, 3, 4-thiadiazol-2-yl] acetamides were synthesized with a prospective exploration of “lead hopping”, using pharmacophoric elements for in vivo anticonvulsant activity. This yielded three potent candidates (5i, 5t, and 5u) in the preliminary screening employing the maximal electroshock seizure (MES) and the subcutaneous pentylenetetrazole (scPTZ) test, ...