Silyl modification of biologically active compounds. 13. Synthesis, cytotoxicity and antibacterial action of N-methyl-N-(2-triorganylsiloxyethyl)-1, 2, 3, 4-tetrahydro (iso) …

…, S Grinberga, I Shestakova, V Nikolajeva…

文献索引：Zablotskaya, Alla; Segal, Izolda; Popelis, Yuris; Grinberga, Solveiga; Shestakova, Irina; Nikolajeva, Vizma; Eze, Daina Applied Organometallic Chemistry, 2013 , vol. 27, # 2 p. 114 - 124

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被引用次数: 3

摘要

Functional groups containing silicon might provide lipophilicity to a drug, allowing it to pass the cell membrane by passive diffusion. This strategy has been successfully applied in the antitumour drug analogues silatecans (silicon-containing camptothecins)[1, 2] and silaplatins (cisplatin analogues),[3] the HIV-1 reverse transcriptase inhibitor TSAO-T [4] and the effective anabolic'silabolin'.[5] Some silicon-containing drugs have entered phase I or ...