Reductive amination of carboxylic acids and [11 C] magnesium halide carboxylates

C Perrio-Huard, C Aubert, MC Lasne

文献索引：Perrio-Huard, Cecile; Aubert, Catherine; Lasne, Marie-Claire Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 3 p. 311 - 316

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被引用次数: 25

摘要

The reductive amination of carboxylic acids was shown to be promoted by 2-chloropyridine hydrochloride (3 eq). It allowed the one-pot preparation of N-alkylamines in yields up to 93% from carboxylic acid (1 eq), amine (1 eq) and sodium borohydride (5 molar eq). The reaction, carried out with [11C] magnesium halide carboxylates (11C, β+, t1/2∶ 20 min), led to N- [11C] alkylamines in 20–25% radiochemical yields (decay corrected to the end of ...