Organic letters

Effects of a Flexible Alkyl Chain on a Ligand for CuAAC Reaction

K Asano, S Matsubara

文献索引：Asano, Keisuke; Matsubara, Seijiro Organic Letters, 2010 , vol. 12, # 21 p. 4988 - 4991

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被引用次数: 33

摘要

Imidazole derivatives substituted by a normal alkyl group are shown to be efficient as a ligand for the copper (Ι)-catalyzed azide− alkyne cycloaddition (CuAAC) reaction. An alkyl chain on the imidazole ligands shows an efficient steric effect and benefits the reaction. Such functionalities of an alkyl chain allow a rapid CuAAC reaction of even a bulky alkyne, which has been difficult to perform under conventional conditions.