Organic letters

Effects of a Flexible Alkyl Chain on a Ligand for CuAAC Reaction

K Asano, S Matsubara

Index: Asano, Keisuke; Matsubara, Seijiro Organic Letters, 2010 , vol. 12, # 21 p. 4988 - 4991

Full Text: HTML

Citation Number: 33

Abstract

Imidazole derivatives substituted by a normal alkyl group are shown to be efficient as a ligand for the copper (Ι)-catalyzed azide− alkyne cycloaddition (CuAAC) reaction. An alkyl chain on the imidazole ligands shows an efficient steric effect and benefits the reaction. Such functionalities of an alkyl chain allow a rapid CuAAC reaction of even a bulky alkyne, which has been difficult to perform under conventional conditions.