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Tetrahedron

Empirical method for predicting enantioselectivity in catalytic reactions: Demonstration with lipase and oxazaborolidine

T Ema, N Ura, M Yoshii, T Korenaga, T Sakai

文献索引:Ema, Tadashi; Ura, Norichika; Yoshii, Masataka; Korenaga, Toshinobu; Sakai, Takashi Tetrahedron, 2009 , vol. 65, # 46 p. 9583 - 9591

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被引用次数: 10

摘要

We derived a novel equation capable of predicting the degree of enantioselectivity in a catalytic reaction without any knowledge of the reaction mechanism and/or the transition- state structure, and tested the validity of this equation by changing substrates systematically in the lipase or oxazaborolidine-catalyzed reactions. A good correlation was observed between the predicted and observed E values, and the stereochemistry of the products ...