Synthesis of diaminobutane derivatives as potent Ca 2+-Permeable AMPA receptor antagonists

Y Yoneda, S Kawajiri, M Sugimura, K Osanai…

文献索引：Yoneda, Yoshiyuki; Kawajiri, Shinichi; Sugimura, Masunobu; Osanai, Ken; Kito, Fusako; Ota, Emi; Mimura, Tetuya Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 19 p. 2663 - 2666

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被引用次数: 9

摘要

We synthesized diaminobutane derivatives as potent Ca2+-permeable AMPA receptor antagonists with non-hypotensive activity. Compound 10c showed selective Ca2+- permeable AMPA receptor antagonist activity and neuroprotective effects in transient global ischemia models in gerbils.