Intermediates in the Hantzsch thiazole synthesis

RS Egan, J Tadanier, DL Garmaise…

文献索引：Egan,R.S. et al. Journal of Organic Chemistry, 1968 , vol. 33, # 12 p. 4422 - 4426

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被引用次数: 22

摘要

The reaction of N-methyl-pdimethylaminothiobeneamide (3) with B number of a-halo ketones and one a-haloaldehyde gave stable Phydroxythiaaolinium salts (4) which could be subsequently dehydrated to the thiaaolium salts (5). When the intermediates were also substituted in the 5 position, both possible diastereoisomeric forms were detected by nmr spectroscopy. The effects of acidification and temperature variation on the nmr spectra ...