Anthelmintic quaternary salts. II. Thiazolium salts

DL Garmaise, CH Chambers…

文献索引：Garmaise,D.L. et al. Journal of Medicinal Chemistry, 1968 , vol. 11, # 6 p. 1205 - 1208

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被引用次数: 15

摘要

As part of a continuing program of structure-activity relations among anthelmintics in which two nitrogen atoms bearing a single positive charge are linked by an odd number of methine groups,'a series of 2-(p-dimethylaminopheny1)-3-methylthiazolium salts were synthesized and evaluated for anthelmintic activity. Chemistry.-The simplest route to the desired compounds appeared to be the quaternization of 2-p-dimethylaminophenylthiazoles. Thus ...