General One??Pot Reductive gem??Bis??Alkylation of Tertiary Lactams/Amides: Rapid Construction of 1??Azaspirocycles and Formal Total Synthesis of (±)?? …

…, JM Luo, XE Xia, Y Wang, PQ Huang

文献索引：Xiao, Kai-Jiong; Luo, Jie-Min; Xia, Xiao-Er; Wang, Yu; Huang, Pei-Qiang Chemistry - A European Journal, 2013 , vol. 19, # 39 p. 13075 - 13086

全文：HTML全文

被引用次数: 36

摘要

Abstract Amides are a class of highly stable and readily available compounds. The amide functional group constitutes a class of powerful directing/activating and protecting group for C [BOND] C bond formation. Tertiary tert-alkylamine, including 1-azaspirocycle is a key structural feature found in many bioactive natural products and pharmaceuticals. The transformation of amides into tert-alkylamines generally requires several steps. In this ...