Tetrahedron Letters

An efficient two-step synthesis of mono-, di-and triureas from resin-bound amides

A Nefzi, NA Ong, RA Houghten

文献索引：Nefzi, Adel; Ong, Nhi A.; Houghten, Richard A. Tetrahedron Letters, 2000 , vol. 41, # 29 p. 5441 - 5446

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被引用次数: 19

摘要

An efficient method for the solid-phase synthesis of mono-, di-and triureas from resin-bound monoamines, diamines and triamines is described. The exhaustive reduction of solid support-bound amides generated the requisite amines, which, following treatment with isocyanates and cleavage, provided the corresponding ureas in high purity and good yields.