Organic letters

A general method for the synthesis of unsymmetrically substituted ureas via palladium-catalyzed amidation

BJ Kotecki, DP Fernando, AR Haight, KA Lukin

文献索引：Kotecki, Brian J.; Fernando, Dilinie P.; Haight, Anthony R.; Lukin, Kirill A. Organic Letters, 2009 , vol. 11, # 4 p. 947 - 950

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被引用次数: 51

摘要

A general and practical method for the preparation of unsymmetrically substituted ureas has been developed utilizing palladium-catalyzed amidation. Both aryl bromides and chlorides, as well as heteroaryl chlorides, have been coupled to aryl, benzyl, and aliphatic ureas by using a novel nonproprietary bipyrazole ligand (bippyphos).