Tetrahedron

Evidence for a common selenolate intermediate in the glutathione peroxidase-like catalysis of α-(phenylselenenyl) ketones and diphenyl diselenide

L Engman, C Andersson, R Morgenstern, IA Cotgreave…

文献索引：Engman, Lars; Andersson, Claes; Morgenstern, Ralf; Cotgreave, Ian A.; Andersson, Carl-Magnus; Hallberg, Anders Tetrahedron, 1994 , vol. 50, # 9 p. 2929 - 2938

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被引用次数: 54

摘要

The glutathione peroxidase-like catalysis of α-(phenylselenenyl) ketones was investigated. Degradation studies demonstrated the rapid cleavage of the aliphatic carbon-selenium bond of α-(phenylselenenyl) ketones by glutathione at pH 6.9 in a methanolic phosphate buffer under argon. On treatment with excess glutathione under aerobic conditions, α- (phenylselenenyl) ketones, S-(phenylselenenyl) glutathione and diphenyl diselenide were ...