Tetrahedron letters

Titanium fluoride complexes as catalysts for the enantioselective addition of Me 3 Al to aldehydes

BL Pagenkopf, EM Carreira

文献索引：Pagenkopf, Brian L.; Carreira, Erick M. Tetrahedron Letters, 1998 , vol. 39, # 52 p. 9593 - 9596

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被引用次数: 81

摘要

We report a Ti (IV) catalyst prepared in situ from TiF4 for the asymmetric addition of trimethylaluminum to aldehydes. The process we detail herein does not necessitate the use of excess trimethylaluminum or Ti (IV) reagent. Good enantioselectivities are achieved with a variety of aromatic and heteroaromatic aldehydes with the products isolated in high yield.