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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

The Palladium??Catalyzed Aerobic Kinetic Resolution of Secondary Alcohols: Reaction Development, Scope, and Applications

DC Ebner, JT Bagdanoff, EM Ferreira…

文献索引：Ebner, David C.; Bagdanoff, Jeffrey T.; Ferreira, Eric M.; McFadden, Ryan M.; Caspi, Daniel D.; Trend, Raissa M.; Stoltz, Brian M. Chemistry - A European Journal, 2009 , vol. 15, # 47 p. 12978 - 12992

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被引用次数: 52

摘要

Abstract The first palladium-catalyzed enantioselective oxidation of secondary alcohols has been developed, utilizing the readily available diamine (−)-sparteine as a chiral ligand and molecular oxygen as the stoichiometric oxidant. Mechanistic insights regarding the role of the base and hydrogen-bond donors have resulted in several improvements to the original system. Namely, addition of cesium carbonate and tert-butyl alcohol greatly enhances ...

(+/-)-methyl 3-hydroxy-2-methylcyclopent-1-enecarboxylate结构式

(+/-)-methyl 3-...

~%

1-Cyclopentene-1-carboxylicacid, 2-methyl-3-oxo-, methyl ester结构式

1-Cyclopentene-...

(3s)-3-羟基-2-甲基-1-环戊烯-1-羧酸甲酯结构式

(3s)-3-羟基-2-甲基-...

(3-羟基-3-苯基丙基)氨基甲酸叔丁酯结构式

(3-羟基-3-苯基丙基)氨基甲酸叔丁酯

~%

(3-氧代-3-苯丙基)氨基甲酸叔丁酯结构式

(3-氧代-3-苯丙基)氨基甲酸叔丁酯

(S)-tert-Butyl (3-hydroxy-3-phenylpropyl)carbamate结构式

(S)-tert-Butyl ...

(3-羟基-3-苯基丙基)氨基甲酸叔丁酯结构式

(3-羟基-3-苯基丙基)氨基甲酸叔丁酯

~%

(3-氧代-3-苯丙基)氨基甲酸叔丁酯结构式

(3-氧代-3-苯丙基)氨基甲酸叔丁酯

(S)-tert-Butyl (3-hydroxy-3-phenylpropyl)carbamate结构式

(S)-tert-Butyl ...

胡椒醛结构式

甲基锂结构式

~%

1-(苯并[d] [1,3]二氧杂环戊烯-5-基)乙醇结构式

1-(苯并[d] [1,3]二...

(+/-)-1-(3,5-di-tert-butylphenyl)ethanol结构式

(+/-)-1-(3,5-di...

~99%

1-(3,5-di-tert-butylphenyl)ethanone结构式

1-(3,5-di-tert-...

(+/-)-1-(3,5-di-tert-butylphenyl)ethanol结构式

(+/-)-1-(3,5-di...

~%

(S)-(-)-1-(3,5-di-tert-butylphenyl)ethanol结构式

(S)-(-)-1-(3,5-...

1-(3,5-di-tert-butylphenyl)ethanone结构式

1-(3,5-di-tert-...

2-phenylcyclopent-2-en-1-ol结构式

2-phenylcyclope...

~%

未登录结构式

2-Phenylcyclopentene-3-one结构式

2-Phenylcyclope...

(+/-)-methyl 3-hydroxy-2-methylcyclopent-1-enecarboxylate结构式

(+/-)-methyl 3-...

~%

1-Cyclopentene-1-carboxylicacid, 2-methyl-3-oxo-, methyl ester结构式

1-Cyclopentene-...

(3s)-3-羟基-2-甲基-1-环戊烯-1-羧酸甲酯结构式

(3s)-3-羟基-2-甲基-...

1-环丙基乙醇结构式

1-环丙基乙醇

~%

环丙甲基酮结构式

环丙甲基酮

(s)-1-cyclopropylethanol结构式

(s)-1-cycloprop...

2-bromocyclopent-2-en-1-ol结构式

2-bromocyclopen...

~%

2-溴环戊-2-烯酮结构式

2-溴环戊-2-烯酮

(1S)-2-bromocyclopent-2-en-1-ol结构式

(1S)-2-bromocyc...

呋喃结构式

2-异丙氧基-4,4,5,5-四甲基-1,3,2-二氧硼烷结构式

2-异丙氧基-4,4,5,5-...

~81%

2-(4,4,5,5-四甲基-1,3,2-二氧杂硼烷-2-基)-1H-吲哚结构式

2-(4,4,5,5-四甲基-...

未登录结构式

~%

未登录结构式

3-methyl-2-phenylcyclopent-2-en-1-one结构式

3-methyl-2-phen...

对溴甲苯结构式

2-异丙氧基-4,4,5,5-四甲基-1,3,2-二氧硼烷结构式

2-异丙氧基-4,4,5,5-...

~97%

4,4,5,5-四甲基-2-(对甲苯基)-1,3,2-二氧环戊硼烷结构式

4,4,5,5-四甲基-2-(...

1-溴-3,4-(亚甲基二氧基)苯结构式

1-溴-3,4-(亚甲基二氧基)苯

2-异丙氧基-4,4,5,5-四甲基-1,3,2-二氧硼烷结构式

2-异丙氧基-4,4,5,5-...

~99%

3.4-(亚甲二氧基)苯硼酸频呢醇酯结构式

3.4-(亚甲二氧基)苯硼酸频呢醇酯

(+/-)-2-bromocyclohex-2-enol结构式

(+/-)-2-bromocy...

~%

2-溴-2-环己烯-1-酮结构式

2-溴-2-环己烯-1-酮

(+/-)-2-bromocyclohex-2-enol结构式

(+/-)-2-bromocy...

2-IODOCYCLOPENT-2-ENONE结构式

2-IODOCYCLOPENT...

4-甲氧基苯硼酸频那醇酯结构式

4-甲氧基苯硼酸频那醇酯

~91%

2-(4-methoxyphenyl)cyclopent-2-en-1-one结构式

2-(4-methoxyphe...

2-Phenylcyclopentene-3-one结构式

2-Phenylcyclope...

~89%

2-phenylcyclopent-2-en-1-ol结构式

2-phenylcyclope...

(+/-)-2-phenylcyclohex-2-enol结构式

(+/-)-2-phenylc...

~%

2-phenylcyclohex-2-en-1-one结构式

2-phenylcyclohe...

(1S)-2-phenylcyclohex-2-en-1-ol结构式

(1S)-2-phenylcy...