Synthesis of the cytochalasin D isoindolone unit: solutions to the problem of regiochemistry in N-benzoylpyrrolinone Diels-Alder reactions

E Vedejs, JB Campbell Jr, RC Gadwood…

文献索引：Vedejs; Campbell Jr.; Gadwood; et al. Journal of Organic Chemistry, 1982 , vol. 47, # 8 p. 1534 - 1546

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被引用次数: 64

摘要

(1) SW Tanenbaum, Ed.,'Frontier8 of Biology", North-Holland Publishing Co., New York, 1980, Vol. 46.(2) C. T am, ref 1, Chapter 2.(3) W. Keller-Shierlein and E. Kupfer, Helu. Chim. Acta, 62, 1501, 1525 (1979). the first cytochalasin to be identified and remains the most important member of the series due to its fascinating biological properties. Cytochalasin D (2, an [ll] cytochalasan) is also highly potent and like cytochalasin B has been used ...