2-Iminopyrrolidines as Potent and Selective Inhibitors of Human Inducible Nitric Oxide Synthase||
…, L Swenton, GM Jerome, CM Kornmeier…
文献索引：Hagen, Timothy J.; Bergmanis, Arija A.; Kramer, Steven W.; Fok, Kam F.; Schmelzer, Albert E.; Pitzele, Barnett S.; Swenton, Lydia; Jerome, Gina M.; Kornmeier, Christine M.; Moore, William M.; Branson, Linda F.; Connor, Jane R.; Manning, Pamela T.; Currie, Mark G.; Hallinan, E. Ann Journal of Medicinal Chemistry, 1998 , vol. 41, # 19 p. 3675 - 3683
A series of substituted 2-iminopyrrolidines has been prepared and shown to be potent and selective inhibitors of the human inducible nitric oxide synthase (hiNOS) isoform versus the human endothelial nitric oxide synthase (heNOS) and the human neuronal nitric oxide synthase (hnNOS). Simple substitutions at the 3-, 4-, or 5-position afforded more potent analogues than the parent 2-iminopyrrolidine 1. The effect of ring substitutions on both ...
