Novel quinolizidinyl derivatives as antiarrhythmic agents

I Vazzana, R Budriesi, E Terranova, P Ioan…

文献索引：Vazzana, Iana; Budriesi, Roberta; Terranova, Emanuela; Ioan, Pierfranco; Ugenti, Maria Paola; Tasso, Bruno; Chiarini, Alberto; Sparatore, Fabio Journal of Medicinal Chemistry, 2007 , vol. 50, # 2 p. 334 - 343

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被引用次数: 14

摘要

Eighteen analogues of lidocaine, mexiletine, and procainamide were synthesized, replacing their aminoalkyl chains with the rigid and cumbersome quinolizidine nucleus. The target compounds were tested for antiarrhythmic, inotropic, and chronotropic effects on isolated guinea pig (gp) heart tissues and to assess calcium antagonist activity. Most compounds exhibited from moderate to high antiarrhythmic activity, and compounds 7, 9, and 19 were ...