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Deciphering the activation sequence of ferrociphenol anticancer drug candidates

…, EA Hillard, A Vessières, D Hamels…

文献索引:Hamels, Didier; Dansette, Patrick M.; Hillard, Elizabeth A.; Top, Siden; Vessieres, Anne; Herson, Patrick; Jaouen, Gerard; Mansuy, Daniel Angewandte Chemie - International Edition, 2009 , vol. 48, # 48 p. 9124 - 9126

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被引用次数: 38

摘要

Abstract The complete oxidation sequence of a model for ferrociphenols, a new class of anticancer drug candidate, is reported. Cyclic voltammetry was used to monitor the formation of oxidation intermediates on different timescales, thereby allowing the electrochemical characterization of both the short-lived and stable species obtained from the successive electron-transfer and deprotonation steps. The electrochemical preparation of the ...