Synthesis and biological activity of certain 3, 4-disubstituted pyrazolo [3, 4-d] pyrimidine nucleosides

…, RB Davidson, RK Robins, GR Revankar

文献索引：Cottam; Petrie; McKernan; Goebel; Dalley; Davidson; Robins; Revankar Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1119 - 1127

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被引用次数: 55

摘要

A number of 3, kdisubstituted pyrazolo [3, 4-d] pyrimidine ribonucleosides were synthesized and tested for their biological activity. Glycosylation of persilylated as well as nonsilylated 3- bromoallopurinol with lO-acety1-2, 3, 5-tri-O-benzoyl-D-ribofuranose (4) provided the key intermediate 3-bromo-1-(2, 3, 5-tri-O-benzoyl-~-~-ribofuranosyl)-pyrazolo [3, 4-d] pyrimidin-4 (5H)-one (5a). Similar glycosylations of 3-cyanoallopurinol and 3-(methylthio) allopurinol ...