N-Aroylated isatins: Antiglycation activity

…, UR Mughal, A Khan, F Naz, S Perveen…

文献索引：Khan, Khalid Mohammed; Mughal, Uzma Rasool; Khan, Ambreen; Naz, Farzana; Perveen, Shahnaz; Choudhary, M. Iqbal Letters in Drug Design and Discovery, 2010 , vol. 7, # 3 p. 188 - 193

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被引用次数: 10

摘要

A series of N-aroylated isatins 1-15 was synthesized and evaluated for their antiglycation activity. All compounds showed a varying degree of glycation inhibitory activity with IC50 values between 18.01±0.05-693.7±3.0 μM, when compared with the standard (aminoguanidine) having an IC50= 268.7±12.4 μM. Compound 1 was found to be the most active member of this series with an IC50= 18.01±0.05 μM. Compound 10 showed an ...