Hydroxy derivatives of S-2-(3-aminopropylamino) ethyl dihydrogen phosphorothioate and related compounds as antiradiation agents

JR Piper, LM Rose, TP Johnston…

文献索引：Piper,J.R. et al. Journal of Medicinal Chemistry, 1975 , vol. 18, p. 803 - 812

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被引用次数: 14

摘要

The high antiradiation activity and low toxicity of sodium 3-amino-2-hydroxypropyl hydrogen phosphorothioate (1) suggested the introduction of hydroxyl groups into other types of radioprotective phosphorothioates. A number of such compounds were synthesized, including S-3-(3-aminopropylamino)-2-hydroxypropyl dihydrogen phosphorothioate (1 1, n= 3), S-2-(3-amino-2-hydroxypropylamino) ethyl dihydrogen phosphorothioate (20) and its ...