The Journal of Organic Chemistry

1, 2-Bis (diphenylphosphino)-1-cyclohexylethane. A new chiral phosphine ligand for catalytic chiral hydrogenations

DP Riley, RE Shumate

文献索引：Riley, Dennis P.; Shumate, Robert E. Journal of Organic Chemistry, 1980 , vol. 45, # 25 p. 5187 - 5193

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被引用次数: 69

摘要

The new chiral bidentate phosphine ligand (R)-1, 2-bis (diphenylphosphino)-l- cyclohexylethane ((R)-Cycphos) has been prepared. The rhodium (1) cationic complex of this phosphine serves as an effective homogeneous asymmetric hydrogenation catalyst for the reduction of (2)-a-amidoacrylic acids at ambient temperature and pressure. Optical yields for the corresponding (S)-a-amino acid derivatives that are produced are generally ...