Chemoenzymic production of lactams from aliphatic α, ω-dinitriles

…, A Eisenberg, EC Hann, R DiCosimo

文献索引：Gavagan, John E.; Fager, Susan K.; Fallon, Robert D.; Folsom, Patrick W.; Herkes, Frank E.; Eisenberg, Amy; Hann, Eugenia C.; DiCosimo, Robert Journal of Organic Chemistry, 1998 , vol. 63, # 14 p. 4792 - 4801

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被引用次数: 65

摘要

Five-and six-membered ring lactams have been prepared by first converting an aliphatic α, ω-dinitrile to an ω-cyanocarboxylic acid ammonium salt, using a microbial cell catalyst having an aliphatic nitrilase activity (Acidovorax facilis 72W, ATCC 55746) or a combination of nitrile hydratase and amidase activities (Comamonas testosteroni 5-MGAM-4D, ATCC 55744). The ω-cyanocarboxylic acid ammonium salt was then directly converted to the ...