Synthesis and evaluation of c-Src kinase inhibitory activity of pyridin-2 (1H)-one derivatives

K Chand, S Prasad, RK Tiwari, AN Shirazi, S Kumar…

文献索引：Chand, Karam; Prasad, Suchita; Tiwari, Rakesh K.; Shirazi, Amir N.; Kumar, Sumit; Parang, Keykavous; Sharma, Sunil K. Bioorganic Chemistry, 2014 , vol. 53, p. 75 - 82

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被引用次数: 6

摘要

Abstract Src kinase, a prototype member of the Src family of kinases (SFKs), is over- expressed in various human tumors, and has become a target for anticancer drug design. In this perspective, a series of eighteen 2-pyridone derivatives were synthesized and evaluated for their c-Src kinase inhibitory activity. Among them, eight compounds exhibited c- Src kinase inhibitory activity with IC 50 value of less than 25 μM. Compound 1-[2-( ...