Robust Synthesis of Methyl 5-Chloro-4-fluoro-1 H-indole-2-carboxylate: A Key Intermediate in the Preparation of an HIV NNRTI Candidate

BA Mayes, NC Chaudhuri, CP Hencken…

文献索引：Organic Process Research and Development, , vol. 14, # 5 p. 1248 - 1253

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被引用次数: 10

摘要

... entry 8).(17) After addition of the aqueous quenching solutions, the organic solvents were ... the ultimate esterification step, thus bypassing the subsequent ethanol/water precipitation procedure which was ... After 3 h, in-process HPLC analysis indicated complete conversion to the ...