A SIMPLIFIED SYNTHESIS OF ETHYL 5-CHLORO-4-FLUORO-1 H-INDOLE-2-CARBOXYLATE AND ETHYL 5-CHLORO-6-FLUORO-1 HH-INDOLE-2- …

R Silvestri, GD Martino, G Sbardella

文献索引：Silvestri, Romano; Martino, Gabriella De; Sbardella, Gianluca Organic Preparations and Procedures International, 2002 , vol. 34, # 5 p. 517 - 520

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被引用次数: 2

摘要

During a search for novel anti-HIV-1 agents, we planned the synthesis of the indolyl aryl sulfones 7 and 8, whose preparation required ethyl 5-chlorod-fluoro-1H-indole-2- carboxylate (5) and ethyl 5-chloro-4-fluoro-1 H-indole-2-carboxylate (6) as starting materials, respectively (Fig. 1). I