Tetrahedron letters

Ortho lithiation of 2-, 3-, and 4-methoxypyridines

DL Comins, DH LaMunyon

文献索引：Tetrahedron Letters, , vol. 29, # 7 p. 773 - 776

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被引用次数: 91

摘要

Tetrahedron Letters,Vol.29,No.7,pp 773 ... To avoid competing side-reactions from nucleophilic addition of an alkyllithium base to the pyridine nucleus, our'initial studies used lithium diisopropylamide (LDA) as the metalating agent.8 Reaction of P-methoxypyridine (1) with LDA ...