Organic letters

Formal Nucleophilic Substitution of Bromocyclopropanes with Azoles

P Ryabchuk, M Rubina, J Xu, M Rubin

文献索引：Butcher, Kenneth J.; Denton, Steven M.; Field, Stuart E.; Gillmore, Adam T.; Harbottle, Gareth W.; Howard, Roger M.; Laity, Daniel A.; Ngono, Christian J.; Pibworth, Benjamin A. Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1192 - 1200

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被引用次数: 21

摘要

... KOH (3.0 equiv), azole (1.5–2 equiv), bromocyclopropane (1.0 equiv), THF (5 mL), 55 °C, 12–18 h; (b) t-BuOK (2–3 ... Meanwell , NA J. Med. ... Qiao, Jennifer X.; Cheney, Daniel L.; Alexander, Richard S.; Smallwood, Angela M.; King, Sarah R.; He, Kan; Rendina, Alan R.; Luettgen ...