Enantioselective and diastereoselective molecular recognition of cyclic dipeptides by a C2 macrolactam Host

MF Cristofaro, AR Chamberlin

文献索引：Cristofaro, Michael F.; Chamberlin, A. Richard Journal of the American Chemical Society, 1994 , vol. 116, # 12 p. 5089 - 5098

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被引用次数: 30

摘要

Abstract: Two synthetic, optically active, C2 symmetric macrolactam hosts llb and llc have been synthesized from L-leucine, and other simple starting materials, in an 1 1-step, convergent synthesis. These new macrocycles, which were conceived with the aid of current molecular modeling software, were designed to complex neutral amides in organic solvents through complementary intermolecular hydrogen bonding. The hosts, which are made up ...