Abstract: Two synthetic, optically active, C2 symmetric macrolactam hosts llb and llc have been synthesized from L-leucine, and other simple starting materials, in an 1 1-step, convergent synthesis. These new macrocycles, which were conceived with the aid of current molecular modeling software, were designed to complex neutral amides in organic solvents through complementary intermolecular hydrogen bonding. The hosts, which are made up ...
