Synlett

Lipase-catalyzed kinetic resolution of 4-(N-Boc-amino)-1-alken-3-ols

T Oshitari, T Mandai

文献索引：Oshitari, Tetsuta; Mandai, Tadakatsu Synlett, 2003 , # 15 p. 2374 - 2376

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被引用次数: 4

摘要

Recently we have developed an efficient lipase-catalyzed kinetic resolution of syn- and anti-methyl 2-substituted 3-hydroxy-4-pentenoates, [9] which allows a ready access to syn- and anti-1,2-amino alcohols with high enantiomeric purity through the stereochemically reliable Curtius rearrangement of the corresponding carboxylic acids. Encouraged by these fruitful results, we then explored the kinetic resolution of acyclic 1,2-amino alcohols that would be more ...