Taxol (l), an antimicrotubule agent isolated from the bark of Taxus brevifolia,'has recently attracted much attantion because of its efficacy in the treatment of various types of cancer. 2 One major impediment to the wide use of tax01 in cancer chemotherapy is its extremely limited availability. Also, chemical complexity has prohibited the commercial production of 1 by total~ ynthesis.~ Thus, a viable approach for the preparation of 1 is to utilize more ...
