Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease

P Munoz-Ruiz, L Rubio…

文献索引：Agarwal; Jalluri; DeWitt Blanton Jr.; Taylor Synthetic Communications, 1993 , vol. 23, # 8 p. 1101 - 1110

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被引用次数: 141

摘要

... Volume: Page: ... bond type (amide or carbamate) in the linker, which is inserted in the last step of the synthetic pathway, as ... by treatment with the corresponding 9-alkylaminotetrahydroacridines 1a−i generated the desired dual binding site inhibitors 3−23 in yields ...