Hansch analysis of substituted benzoic acid benzylidene/furan-2-yl-methylene hydrazides as antimicrobial agents

P Kumar, B Narasimhan, D Sharma, V Judge…

文献索引：Kumar, Pradeep; Narasimhan, Balasubramanian; Sharma, Deepika; Judge, Vikramjeet; Narang, Rakesh European Journal of Medicinal Chemistry, 2009 , vol. 44, # 5 p. 1853 - 1863

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被引用次数: 67

摘要

A series of substituted hydrazide derivatives have been synthesized and screened for their in vitro antimicrobial activities against five representative microorganisms. The results of antimicrobial study indicated that the presence of electron withdrawing groups on the benzoic acid moiety improved antimicrobial activity. Further, the presence of heterocyclic ring furan does not improve the antimicrobial activity of substituted hydrazides. To ...