Microwave-assisted synthesis, molecular docking and antitubercular activity of 1, 2, 3, 4-tetrahydropyrimidine-5-carbonitrile derivatives

…, SC Dinda, D Naik, SP Seenivasan, V Kumar…

文献索引：Mohan, Sahoo Biswa; Ravi Kumar; Dinda; Naik; Prabu Seenivasan; Kumar, Vanaja; Rana, Dharmarajsinh N.; Brahmkshatriya, Pathik S. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7539 - 7542

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被引用次数: 20

摘要

Based on bioisosteric similarities with isoniazid, a series of 1, 2, 3, 4-tetrahydropyrimidine-5- carbonitrile derivatives has been designed. The target compounds have been synthesized by multicomponent reaction which involves one-pot organic reactions using ethylcyanoacetate, urea/thiourea and arylaldehydes in presence of ethanolic K2CO3. Two methodologies, conventional and microwave-assisted, have been adopted for the ...