Synthesis and anti-HIV-1 activity of new delavirdine analogues carrying arylpyrrole moieties.

…, M Mura, L Vargiu, C Murgioni, P La Colla

文献索引：Pinna; Loriga; Murineddu; Grella; Mura; Vargiu; Murgioni; La Colla Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 11 p. 1406 - 1411

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被引用次数: 48

摘要

In our search for novel anti-human immunodeficiency virus (HIV)-1 agents, 14 delavirdine analogues were synthesized and evaluated as potential anti-HIV-1 agents in cell-based assays. Compound 1Aa exhibited potent and selective anti-HIV-1 activity in acutely infected MT4 cells, with effective concentration (EC 50) values in the submicromolar range.