Tetrahedron Letters

Conjugate reduction of polyfunctional α, β-unsaturated carbonyl compounds using [(Ph 3 P) CuH] 6. Compatibility with halogen, sulfonate, and γ-oxygen and sulfur …

TM Koenig, JF Daeuble, DM Brestensky, JM Stryker

文献索引：Koenig, Thomas M.; Daeuble, John F.; Brestensky, Donna M.; Stryker, Jeffrey M. Tetrahedron Letters, 1990 , vol. 31, # 23 p. 3237 - 3240

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被引用次数: 85

摘要

Abstract In contrast to organocuprate conjugate addition and standard methods for conjugate reduction, use of the stable copper (I) hydride cluster,[(Ph 3 P) CuH] 6, allows chemoselective conjugate reduction of α, β-unsaturated carbonyl compounds substituted at the γ-position with leaving groups. In addition, the compatibility of the conjugate reduction with organic halides and sulfonate groups is demonstrated.