Practical Imidazole??Based Phosphine Ligands for Selective Palladium??Catalyzed Hydroxylation of Aryl Halides

…, J Huang, A Zapf, R Kadyrov, A Börner…

文献索引：Schulz, Thomas; Torborg, Christian; Schaeffner, Benjamin; Huang, Jun; Zapf, Alexander; Kadyrov, Renat; Boerner, Armin; Beller, Matthias Angewandte Chemie - International Edition, 2009 , vol. 48, # 5 p. 918 - 921

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被引用次数: 160

摘要

Phenols are an integral part of numerous pharmaceuticals, polymers, and natural products.[1] In the past the nonoxidative preparation of this class of compounds involved nucleophilic aromatic substitution of activated aryl halides, often under harsh reaction conditions.[2] Smith, Maleczka, and co-workers reported the preparation of non-ortho- substituted phenols under milder conditions.[3] However, two steps, CH-activation/ ...