Microwave-assisted synthesis of new polysubstituted dienaminoesters and their cyclization to 3-bromo-2 (1 H)-pyridinones

J Adams, A Hardin, F Vounatsos

文献索引：Adams, Jeff; Hardin, Alison; Vounatsos, Filisaty Journal of Organic Chemistry, 2006 , vol. 71, # 26 p. 9895 - 9898

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被引用次数: 21

摘要

To the best of our knowledge, only one method has been reported in the literature describing the synthesis of halogenated N-substituted 2(1H)-pyridinones starting from acyclic substrates. Dechoux and co-workers recently reported a synthetic route to this class of compounds which centered on a Michael-type addition between an amine and a methyl propiolate followed by bromocyclization of the ensuing δ-dienaminoester (Scheme 1). 9 This method was ...