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Tetrahedron

Novel analogues of resveratrol: metabolism and inhibition of colon cancer cell proliferation

…, RG Britton, H Cai, AJ Gescher, K Brown, PR Jenkins

文献索引:Simon, Charles; Britton, Robert G.; Cai, Hong; Gescher, Andreas J.; Brown, Karen; Jenkins, Paul R. Tetrahedron, 2013 , vol. 69, # 30 p. 6203 - 6212

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被引用次数: 2

摘要

Resveratrol is a phytochemical present in the skin of red grapes, and hence red wine as well as a variety of berries and nuts. It is an anti-oxidant, which has shown cancer chemopreventive properties in preclinical rodent models of carcinogenesis. The bioavailability of resveratrol is low, as it is rapidly metabolised to glucuronides and sulfates. The pharmacological activities of conjugate metabolites of phenols are often much lower ...