Lewis acid-promoted intermolecular acetal-initiated cationic polyene cyclizations

YJ Zhao, SS Chng, TP Loh

文献索引：Zhao, Yu-Jun; Chng, Shu-Sin; Loh, Teck-Peng Journal of the American Chemical Society, 2007 , vol. 129, # 3 p. 492 - 493

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被引用次数: 44

摘要

The intramolecular acetal-initiated cationic polyene cyclization reaction was first introduced by WS Johnson. 1,2 Since then, this method has been extensively developed to afford bicyclic, 2,3 tricyclic, 2,3 tetracyclic, 2,3 and even pentacyclic 2,3 products in respectable to good yields. Asymmetric induction has also been achieved using chiral acetal templates, providing enantiomeric excess of up to 90%. 2 However, there exist some disadvantages in using ...